Interactions of phosphorus-containing dendrimers with liposomes

被引：40

作者：

Wrobel, Dominika ^{[1
]}

Ionov, Maksim ^{[1
]}

Gardikis, Konstantinos ^{[2
]}

Demetzos, Costas ^{[2
]}

Majoral, Jean-Pierre ^{[3
]}

Palecz, Bartlomiej ^{[4
]}

Klajnert, Barbara ^{[1
]}

Bryszewska, Maria ^{[1
]}

机构：

[1] Univ Lodz, Dept Gen Biophys, PL-90237 Lodz, Poland

[2] Sch Pharm, Dept Pharmaceut Technol, Thessaloniki, Greece

[3] CNRS, Lab Chim Coordinat, Toulouse, France

[4] Univ Lodz, Dept Phys Chem, PL-90237 Lodz, Poland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2011年 / 1811卷 / 03期

关键词：

Cationic phosphorus-containing dendrimers; Liposomes; DSC; Anisotropy; Membrane fluidity; SUPPORTED LIPID-BILAYERS; POLY(AMIDOAMINE) DENDRIMERS; PAMAM DENDRIMERS; POLYCATIONIC POLYMERS; MOLECULAR-DYNAMICS; HOLE FORMATION; PORE FORMATION; IN-VITRO; DMPC; PHASE;

D O I：

10.1016/j.bbalip.2010.11.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of cationic phosphorus-containing dendrimers generation 3 and 4 on model DMPC or DPPC lipid membranes was studied. Measurements of fluorescence anisotropy and differential scanning calorimetry (DSC) were applied to assess changes in lipid bilayer parameters, including fluidity, anisotropy, and phase-transition temperature. Interaction with both hydrophobic and hydrophilic regions of the bilayer was followed by these methods. Dendrimers of both generations influence lipid bilayers by decreasing membrane fluidity. The results suggest that dendrimers can interact both with the hydrophobic part and the polar head-group region of the phospholipid bilayer. Higher generation dendrimers interact more strongly with model membranes, and the concentration, as well as the generation, is of similar importance. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：221 / 226

页数：6

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