Rapid onset of bronchodilation with formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler as compared to formoterol alone in patients with COPD

被引：6
|
作者：
Cazzola, Mario [1 ]
Pasqua, Franco [2 ]
Ferri, Luigi [3 ]
Biscione, Gianluca [2 ]
Cardaci, Vittorio [3 ]
Matera, Maria Gabriella [4 ]
机构：
[1] Univ Roma Tor Vergata, Dept Internal Med, Unit Resp Clin Pharmacol, I-00133 Rome, Italy
[2] Hosp San Raffaele, Velletri, Rome, Italy
[3] IRCCS San Raffaele Pisana, Rehabilitat Pneumol, Rome, Italy
[4] Univ Naples 2, Dept Expt Med, Pharmacol Unit, Naples, Italy
来源：
PULMONARY PHARMACOLOGY & THERAPEUTICS | 2011年 / 24卷 / 01期
关键词：
Formoterol; Beclomethasone; Budesonide; COPD; Onset of action; BLOOD MONONUCLEAR-CELLS; ALLERGEN CHALLENGE; SMOOTH-MUSCLE; GLUCOCORTICOIDS; MECHANISMS; RECEPTORS; ASTHMA; LUNG; CORTICOSTEROIDS; TRANSCRIPTION;
D O I：
10.1016/j.pupt.2010.08.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the present study, we examined whether there is a difference in the onset of bronchodilatation between formoterol/beclomethasone 12/200 mu g Modulite and formoterol/budesonide 9/320 mu g Turbuhaler in patients with COPD. We enrolled 28 patients with stable COPD. Both formoterol/beclomethasone and formoterol/budesonide elicited a larger mean FEV1-AUC(0-15min) than formoterol alone, whereas there was no significant difference between their FEV1-AUC(0-15min). Also the change in FEV1 15 min after inhalation of formoterol/beclomethasone combination or formoterol/budesonide combination was greater than that induced by formoterol alone. This study confirms the rapid effect of the inhaled corticosteroid component when combined with formoterol and indicates that the onset of bronchodilation of formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler are similar and greater than formoterol alone in patients with COPD. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：118 / 122
页数：5
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