Antithrombotic activities of fucosylated chondroitin sulfates and their depolymerized fragments from two sea cucumbers

被引：55
|
作者：
Liu, Xiaoxiao [1 ,2 ]
Hao, Jiejie [1 ,2 ]
Shan, Xindi [1 ,2 ]
Zhang, Xiao [1 ,2 ]
Zhao, Xiaoliang [1 ,2 ]
Li, Qinying [1 ,2 ]
Wang, Xiaojiang [1 ,2 ]
Cai, Chao [1 ,2 ]
Li, Guoyun [1 ,2 ]
Yu, Guangli [1 ,2 ,3 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China
[2] Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China
[3] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2016年 / 152卷
关键词：
Fucosylated chondroitin sulfate; Sulfation pattern; Molecular weight; Antithrombotic; Anticoagulant; APOSTICHOPUS-JAPONICUS; ANTICOAGULANT; GLYCOSAMINOGLYCAN;
D O I：
10.1016/j.carbpol.2016.06.106
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Fucosylated chondroitin sulfate (FCS), a glycosaminoglycan extracted from the body wall of sea cucumber, is a promising antithrombotic agent. The chemical structures of FCSc isolated from sea cucumber Cucumaria frondosa and its depolymerized fragment (dFCSc) were characterized for the first time. Additionally, anticoagulant and antithrombotic activities were evaluated in vitro and in vivo. The results demonstrated that dFCSc exhibited better antithrombotic-hemorrhagic ratio than native FCSc on the electrical induced arterial thrombosis model in rats. Compared to FCSt obtained from Thelenota ananas, FCSc possessed different sulfation patterns but similar antithrombotic effects. Therefore, sulfation pattern of FCS might not affect anticoagulation and antithrombosis as much as molecular weight may. Our results proposed a new point of view to understand the structure-activity relationship of FCS as alternative agents. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：343 / 350
页数：8
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