Self-Assembled DNA Nanostructures for Biomedical Applications

被引：19
|
作者：
Song, Linlin [1 ,2 ]
Jiang, Qiao [1 ]
Wang, Zhen-Gang [1 ]
Ding, Baoquan [1 ,2 ]
机构：
[1] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosc, CAS Key Lab Nanosyst & Hierarch Fabricat, 11 BeiYiTiao, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
CHEMNANOMAT | 2017年 / 3卷 / 10期
基金：
美国国家科学基金会;
关键词：
biomedicine; drug delivery; DNA nanostructures; multifunctional materials; smart materials; IN-VIVO STABILITY; ORIGAMI NANOSTRUCTURES; CANCER-THERAPY; DRUG-RESISTANCE; SIRNA DELIVERY; NUCLEIC-ACIDS; LIVING CELLS; COMPLEX; CONSTRUCTION; GOLD;
D O I：
10.1002/cnma.201700158
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DNA has been demonstrated to be a promising engineering material for the fabrication of pre-designed nanostructures and nanodevices, which feature structural programmability, spatial addressability, dynamic mechanics, and biocompatibility. Here, we review the recent progress in the design, construction and biomedical applications of DNA nanostructures, particularly imaging probes and drug delivery carriers. We discuss several key points for in vivo biomedical applications of DNA-based delivery systems, such as the cost and safety issues. In the end, we explore the challenges and opportunities of DNA nanotechnology in the field of nanomedicine.
引用
收藏
页码：713 / 724
页数：12
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