Multiple epigenetic events regulate mating-type switching of fission yeast

被引：0
|
作者：
Klar, AJS [1 ]
Ivanova, AV [1 ]
Dalgaard, JZ [1 ]
Bonaduce, MJ [1 ]
Grewal, SIS [1 ]
机构：
[1] NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Gene Regulat & Chromosome Biol Lab, Frederick, MD 21702 USA
来源：
EPIGENETICS | 1998年 / 214卷
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two epigenetic events at mat1, one of which is DNA strand specific, are required to initiate recombination during mating-type switching. The third, a chromosomally borne imprinted event at the mat2/3 internal regulates silencing and directionality of switching, and prohibits interchromosomal recombination. We speculate that the unit of inheritance in the mat2/3 interval is both DNA plus its associated chromatin structure. Such a control is likely to be essential in maintaining particular states of gene expression during development.
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页码：87 / 99
页数：13
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