The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials

被引：94
|
作者：
Suder, Ellen [1 ]
Furuyama, Wakako [1 ]
Feldmann, Heinz [1 ]
Marzi, Andrea [1 ]
de Wit, Emmie [1 ]
机构：
[1] NIAID, Lab Virol, NIH, Rocky Mt Labs, Hamilton, MT 59840 USA
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2018年 / 14卷 / 09期
关键词：
VSV-EBOV; animal models; clinical trials; filovirus; preclinical testing; phase; 1; 2; 3; PROTECTS NONHUMAN-PRIMATES; MARBURG VIRUS; DOUBLE-BLIND; CHALLENGE; SAFETY; IMMUNOGENICITY; EFFICACY; IMMUNIZATION; ANTIBODIES; INFECTION;
D O I：
10.1080/21645515.2018.1473698
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The devastating Ebola virus (EBOV) epidemic in West Africa in 2013-2016 accelerated the progress of several vaccines and antivirals through clinical trials, including the replication-competent vesicular stomatitis virus-based vaccine expressing the EBOV glycoprotein (VSV-EBOV). Extensive preclinical testing in animal models demonstrated the prophylactic and post-exposure efficacy of this vaccine, identified the mechanism of protection, and suggested it was safe for human use. Based on these data, VSV-EBOV was extensively tested in phase 1-3 clinical trials in North America, Europe and Africa. Although some side effects of vaccination were observed, these clinical trials showed that the VSV-EBOV was safe and immunogenic in humans. Moreover, the data supported the use of VSV-EBOV as an emergency vaccine in individuals at risk for Ebola virus disease. In this review, we summarize the results of the extensive preclinical and clinical testing of the VSV-EBOV vaccine.
引用
收藏
页码：2107 / 2113
页数：7
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