Dysidavarones A-D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara

被引：72

作者：

Jiao, Wei-Hua ^{[1
]}

Huang, Xiao-Jun ^{[2
]}

Yang, Ji-Si ^{[1
]}

Yang, Fan ^{[1
]}

Piao, Shu-Jian ^{[1
]}

Gao, Hao ^{[2
]}

Li, Jia ^{[3
]}

Ye, Wen-Cai ^{[2
]}

Yao, Xin-Sheng ^{[2
]}

Chen, Wan-Sheng ^{[1
]}

Lin, Hou-Wen ^{[1
]}

机构：

[1] Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 01期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

EFFICIENT TOTAL-SYNTHESIS; NATURAL-PRODUCTS; CONFIGURATION; HYDROQUINONE; METABOLITES;

D O I：

10.1021/ol202994c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dysidavarones A-D (1-4), four new sesquiterpene quinones possessing the unprecedented "dysidavarane" carbon skeleton, were isolated from the South China Sea sponge Dysidea avara. The structures were established by spectroscopic methods, and the absolute configurations were determined using quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum and exciton chirality CD method. Their cytotoxic activity against four human cancer cell lines and PTP1B inhibitory activity were also evaluated.

引用

页码：202 / 205

页数：4

共 50 条

[1] Bioactive sesquiterpene quinols and quinones from the marine sponge Dysidea avara
Jiao, Wei-Hua
Xu, Ting-Ting
Gu, Bin-Bin
Shi, Guo-Hua
Zhu, Yan
Yang, Fan
Han, Bing-Nan
Wang, Shu-Ping
Li, Yu-Shan
Zhang, Wei
Li, Jia
Lin, Hou-Wen
[J]. RSC ADVANCES, 2015, 5 (106) : 87730 - 87738
[2] Dysideanones F-G and dysiherbols D-E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara
LIU HongYan
ZHOU Mi
SHANG RuYi
HONG LiLi
WANG GuangHui
TIAN WenJing
JIAO WeiHua
CHEN HaiFeng
LIN HouWen
[J]. Chinese Journal of Natural Medicines, 2022, 20 (02) : 148 - 154
[3] Dysideanones F-G and dysiherbols D-E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara
Liu Hong-Yan
Zhou Mi
Shang Ru-Yi
Hong Li-Li
Wang Guang-Hui
Tian Wen-ling
Hag Wei-Hua
Chen Hai-Feng
Lin Hou-Wen
[J]. CHINESE JOURNAL OF NATURAL MEDICINES, 2022, 20 (02) : 148 - 154
[4] Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara
Jiao, Wei-Hua
Xu, Ting-Ting
Yu, Hao-Bing
Chen, Guo-Dong
Huang, Xiao-Jun
Yang, Fan
Li, Yu-Shan
Han, Bing-Nan
Liu, Xiao-Yan
Lin, Hou-Wen
[J]. JOURNAL OF NATURAL PRODUCTS, 2014, 77 (02): : 346 - 350
[5] A NEW BIOACTIVE DERIVATIVE OF AVAROL FROM THE MARINE SPONGE DYSIDEA-AVARA
CRISPINO, A
DEGIULIO, A
DEROSA, S
STRAZZULLO, G
[J]. JOURNAL OF NATURAL PRODUCTS, 1989, 52 (03): : 646 - 648
[6] SESQUITERPENOID QUINONES FROM THE SPONGE, DYSIDEA-AVARA AS TYROSINE KINASE INHIBITORS
ALVI, KA
CREWS, P
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 161 - ORGN
[7] A New Bioactive Sesquiterpenoid Quinone from the Mediterranean Sea Marine Sponge Dysidea avara
Hamed, Ashraf Nageeb El-Sayed
Waetjen, Wim
Schmitz, Roland
Chovolou, Yvonni
Edrada-Ebel, RuAngelie
Youssef, Diaa T. A.
Kamel, Mohammed Salah
Proksch, Peter
[J]. NATURAL PRODUCT COMMUNICATIONS, 2013, 8 (03) : 289 - 292
[8] Haterumadysins A-D, sesquiterpenes from the Okinawan marine sponge Dysidea chlorea
Ueda, Katsuhiro
Kadekaru, Takashi
Siwu, Eric R. O.
Kita, Masaki
Uemura, Daisuke
[J]. JOURNAL OF NATURAL PRODUCTS, 2006, 69 (07): : 1077 - 1079
[9] STRUCTURE OF 2 BIOLOGICALLY-ACTIVE SESQUITERPENOID AMINO-QUINONES FROM THE MARINE SPONGE DYSIDEA-AVARA
CIMINO, G
DEROSA, S
DESTEFANO, S
CARIELLO, L
ZANETTI, L
[J]. EXPERIENTIA, 1982, 38 (08): : 896 - 896
[10] NEW SESQUITERPENOID HYDROQUINONE AND QUINONES FROM THE OKINAWAN MARINE SPONGE (DYSIDEA SP)
IGUCHI, K
SAHASHI, A
KOHNO, J
YAMADA, Y
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (05) : 1121 - 1123

← 1 2 3 4 5 →