Epigenetic reprogramming in liver fibrosis and cancer

被引：68
|
作者：
Wilson, Caroline L. [1 ]
Mann, Derek A. [1 ]
Borthwick, Lee A. [1 ]
机构：
[1] Newcastle Univ, Inst Cellular Med, Fibrosis Res Grp, Newcastle Upon Tyne, Tyne & Wear, England
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2017年 / 121卷
基金：
英国医学研究理事会;
关键词：
Hepatic Stellate Cell; Hepatocellular carcinoma; DNA methylation; Histone modifications; Non-coding RNAs; HEPATIC STELLATE CELLS; HISTONE DEACETYLASE INHIBITOR; NONALCOHOLIC FATTY LIVER; DNA METHYLATION; HEPATOCELLULAR-CARCINOMA; MYOFIBROBLAST TRANSDIFFERENTIATION; CIRCADIAN-RHYTHM; DOWN-REGULATION; MAMMALIAN DNA; UP-REGULATION;
D O I：
10.1016/j.addr.2017.10.011
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Novel insights into the epigenetic control of chronic liver diseases are now emerging. Recent advances in our understanding of the critical roles of DNA methylation, histone modifications and ncRNA may now be exploited to improve management of fibrosis/cirrhosis and cancer. Furthermore, improved technologies for the detection of epigenetic markers from patients' blood and tissues will vastly improve diagnosis, treatment options and prognostic tracking. The aim of this review is to present recent findings from the field of liver epigenetics and to explore their potential for translation into therapeutics to prevent disease promoting epigenome reprogramming and reverse epigenetic changes. (C) 2017 The Authors. Published by Elsevier B.V.
引用
收藏
页码：124 / 132
页数：9
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