Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis

被引:15
|
作者
Ishida, Masaharu
Sunamura, Makoto
Furukawa, Toru
Akada, Masanori
Fujimura, Hiroko
Shibuya, Emiko
Egawa, Shinichi
Unnof, Michiaki
Horii, Akira
机构
[1] Tohoku Univ, Sch Med, Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Sch Med, Dept Mol Pathol, Sendai, Miyagi 9808575, Japan
[3] Tohoku Univ, Sch Med, Dept Surg Gastroenterol, Sendai, Miyagi 9808575, Japan
[4] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Canc Surg Sect, London W12 0NN, England
关键词
BNIP3; chemosensitivity; gemcitabine; pancreatic cancer; prognosis;
D O I
10.3748/wjg.v13.i34.4593
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic canter cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreatic cancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. (c) 2007 WJG. All rights reserved.
引用
收藏
页码:4593 / 4597
页数:5
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