Whispering-gallery-mode biosensing: label-free detection down to single molecules

被引：1365
|
作者：
Vollmer, Frank [2 ]
Arnold, Stephen [1 ]
机构：
[1] Polytech Univ, MicroParticle PhotoPhys Lab MPL, Brooklyn, NY 11201 USA
[2] Harvard Univ, Rowland Inst, Cambridge, MA 02142 USA
来源：
NATURE METHODS | 2008年 / 5卷 / 07期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1038/nmeth.1221
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding. However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized. Here we describe the enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor, review its current implementations and applications, and discuss its future possibilities.
引用
收藏
页码：591 / 596
页数：6
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