A convenient one-pot synthesis of 4-hydroxycoumarin, 4-hydroxythiocoumarin, and 4-hydroxyquinolin-2(1H)-one

被引：116
|
作者：
Jung, JC [1 ]
Jung, YJ [1 ]
Park, OS [1 ]
机构：
[1] Chungbuk Natl Univ, Coll Nat Sci, Dept Chem, Cheongju 361763, Chungbuk, South Korea
来源：
SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 08期
关键词：
D O I：
10.1081/SCC-100104003
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An improved one-pot synthesis of 4-hydroxycoumarin. 4-hydroxythiocoumarin, and 4-hydroxyquinolin-2(1H)-one from 2-hydroxyacetophenone, 2-mercaptoacetophenone, and 2-aminoacetophenone, respectively, is described. The synthetic strategies involve the acylation and internal ring cyclization. This method is readily amenable to large-scale synthesis of 4-hydroxycoumarin, 4-hydroxythiocoumarin, and 4-hydroxyquinolin-2(1H)-one derivatives in high yields.
引用
收藏
页码：1195 / 1200
页数：6
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