Invasive pneumococcal disease in children with sickle cell disease in the pneumococcal conjugate vaccine era

被引：16

作者：

Martin, Olufunke O. ^{[1
]}

Moquist, Kristin L. ^{[2
]}

Hennessy, Jane M. ^{[2
]}

Nelson, Stephen C. ^{[2
]}

机构：

[1] Michigan State Univ, Coll Human Med, Flint, MI USA

[2] Childrens Hosp & Clin Minnesota, Dept Pediat Hematol Oncol, 2530 Chicago Ave South,CSC-175, Minneapolis, MN 55405 USA

来源：

PEDIATRIC BLOOD & CANCER | 2018年 / 65卷 / 01期

关键词：

invasive pneumococcal disease; sickle cell disease; vaccine;

D O I：

10.1002/pbc.26713

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) can be devastating. We sought to assess the impact of IPD in children with SCD since licensure of the pneumococcal conjugate vaccines (PCVs). We found 11 cases of IPD giving an incidence of 417 per 100,000 person-years, much higher than that reported in children without SCD. Although all isolates were sensitive to penicillin, 89% of isolates were nonvaccine serotypes. Further study is needed to characterize the incidence of and risk factors for the development of IPD in SCD in the PCV era to help drive better prevention strategies.

引用

页数：3

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