Ancient haplotypes of the HLA Class II region

被引：51

作者：

Raymond, CK ^{[1
]}

Kas, A ^{[1
]}

Paddock, M ^{[1
]}

Qiu, RL ^{[1
]}

Zhou, Y ^{[1
]}

Subramanian, S ^{[1
]}

Chang, J ^{[1
]}

Palmieri, A ^{[1
]}

Haugen, E ^{[1
]}

Kaul, R ^{[1
]}

Olson, MV ^{[1
]}

机构：

[1] Univ Washington, Genome Ctr, Dept Med, Seattle, WA 98195 USA

来源：

GENOME RESEARCH | 2005年 / 15卷 / 09期

关键词：

D O I：

10.1101/gr.3554305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Allelic variation in codons that specify amino acids that line the peptide-binding pockets of HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply diverged haplotypes. These haplotypes appear to have been evolving almost independently for tens of millions of years. By complete resequencing of 20 haplotypes across the similar to 100-kbp region that spans the HLA-DQA1, -DQB1, and -DRB1 genes, we provide a detailed view of the way in which the genome structure at this locus has been shaped by the interplay of selection, gene-gene interaction, and recombination.

引用

页码：1250 / 1257

页数：8

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