Peripheral Artery Disease on The Prognosis Value of Patients with Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Retrospective, Single-Center Cohort Study

Objective: The purpose of this investigation aimed to clarify the impact of peripheral artery disease (PAD) on the prognosis value of patients with stable coronary artery dis-ease (CAD) who underwent percutaneous coronary inter-vention (PCI). Methods: The SPSS 16 software was used for secondary analysis of DRYAD database data. A total of 204 patients were enrolled from Shinonoi General Hospital for newly diag-nosed stable CAD and received PCI performance between October 2014 and October 2017. Patients with old myocar-dial infarction (MI) were excluded. We divided patients into two groups with PAD and without PAD. The primary end-points were major adverse cardiac events (MACE, defined as all-cause death, non-fatal MI, and non-fatal stroke) and car-diovascular events (defined as cardiovascular death, non-fatal MI, and non-fatal stroke). The secondary outcomes were the individual components of the composite primary outcomes. The median follow-up time was 783 days. Results: No statistical difference was found between PAD and non-PAD patients of lesional characteristics. Spearman's rank correlations indicate diabetes mellitus (DM) (P = 0.019) and HbA1c (P = 0.009) are positively correlated with PAD. In Kaplan-Meier analysis, patients with PAD predicted poor prog-nosis in MACE (P < 0.05) and cardiovascular events (P < 0.05). In Multivariable Cox proportional hazards analysis, patients with PAD independently predicted MACE and cardiovascular events. Conclusions: PAD is a significant mediator for the prognosis of patients with stable CAD who underwent PCI treatment.