Comparison of the Characteristics of Cytokine Storm and Immune Response Induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections

被引：15

作者：

Liu, Tong ^{[1
]}

Feng, Meng ^{[2
,3
]}

Wen, Zexin ^{[4
]}

He, Yijie ^{[1
]}

Lin, Wei ^{[2
,3
]}

Zhang, Min ^{[1
]}

机构：

[1] Xizang Minzu Univ, Dept Med, Xianyang, Shaanxi, Peoples R China

[2] Shandong First Med Univ, Sch Basic Med, Jinan, Shandong, Peoples R China

[3] Shandong Acad Med Sci, Jinan, Shandong, Peoples R China

[4] Fujian Med Univ, Dept Clin Med, Fuzhou, Fujian, Peoples R China

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2021年 / 14卷

基金：

中国国家自然科学基金;

关键词：

cytokines; coronavirus pneumonia; cytokine storm; immune evasion; interferon; RESPIRATORY SYNDROME-CORONAVIRUS; INHIBITS TYPE-I; INFLAMMATORY CYTOKINES; INTERFERON-PRODUCTION; PROTEIN; RECEPTOR; MACROPHAGES; RECOGNITION; INDUCTION; SPIKE;

D O I：

10.2147/JIR.S329697

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokine storm (CS) is a significant cause of death in patients with severe coronavirus pneumonia. Excessive immune-inflammatory reaction, many inflammatory cell infiltration, and extreme increase of proinflammatory cytokines and chemokines lead to acute lung injury and acute respiratory distress syndrome (ARDS). This review compares the characters of cytokine storms and immune responses caused by three highly pathogenic and infectious coronaviruses (HCoVs), including severe acute respiratory syndrome corona virus (SARS-CoV), Middle East respiratory syndrome-coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and analyzes the possible mechanisms to guide clinical treatment in the future.

引用

页码：5475 / 5487

页数：13

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