Non-parametric group sequential designs in randomized clinical trials

被引:3
|
作者
Bandyopadhyay, U
Biswas, A
机构
[1] Indian Stat Inst, Appl Stat Unit, Kolkata 700035, W Bengal, India
[2] Univ Calcutta, Dept Stat, Kolkata 700019, W Bengal, India
关键词
equivalence; group sequential methods; inverse binomial sampling; repeated significance tests; stopping rule; type 1 error spending function;
D O I
10.1111/1467-842X.00290
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
This paper examines some non-parametric group sequential designs applicable for randomized clinical trials, for comparing two continuous treatment effects taking the observations in matched pairs, or applicable in event-based analysis. Two inverse binomial sampling schemes are considered, of which the second one is an adaptive data-dependent design. These designs are compared with some fixed sample size competitors. Power and expected sample sizes are calculated for the proposed procedures.
引用
收藏
页码:367 / 376
页数:10
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