The effect of ethanol on the formation of N2-ethylidene-dG adducts in mice: implications for alcohol-related carcinogenicity of the oral cavity and esophagus

被引：14

作者：

Yu, Hsu-Sheng

Oyama, Tsunehiro

Matsuda, Tomonari ^{[2
]}

Isse, Toyohi ^{[3
]}

Yamaguchi, Tetsunosuke

Tanaka, Masayuki

Tsuji, Mayumi

Kawamoto, Toshihiro ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Environm Hlth, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

[2] Kyoto Univ, Res Ctr Environm Qual Management, Otsu, Shiga, Japan

[3] Univ Occupat & Environm Hlth, Sch Med, Sect Postgrad Guidance, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

来源：

BIOMARKERS | 2012年 / 17卷 / 03期

关键词：

Acetaldehyde; ALDH2; carcinogenesis; DNA adduct; ethanol; N-2-ethyl-dG; DNA-ADDUCTS; ALDEHYDE DEHYDROGENASE; GENETIC POLYMORPHISMS; KNOCKOUT MICE; ACETALDEHYDE; CANCER; RISK; N-2-ETHYLDEOXYGUANOSINE; IDENTIFICATION; CONSUMPTION;

D O I：

10.3109/1354750X.2012.666675

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study aimed to experimentally confirm that long-term alcohol drinking causes a high risk of oral and esophageal cancer in aldehyde dehydrogenase 2 (ALDH2)-deficient individuals. Aldh2 knockout mice, an animal model of ALDH2-deficiency, were treated with 8% ethanol for 14 months. Levels of acetaldehyde-derived DNA adducts were increased in esophagus, tongue and submandibular gland. Our finding that a lack of Aldh2 leads to more DNA damage after chronic ethanol treatment in mice supports epidemiological findings on the carcinogenicity of alcohol in ALDH2-deficient individuals who drink chronically.

引用

页码：269 / 274

页数：6

共 5 条

[1] The effect of ethanol on the formation of N2-ethylidene-dG adducts in mice: implications for alcohol-related carcinogenicity of the oral cavity and esophagus (vol 17, pg 269, 2012)
Yu, Hsu-Sheng
Oyama, Tsunehiro
Matsuda, Tomonari
Isse, Toyohi
Yamaguchi, Tetsunosuke
Tanaka, Masayuki
Tsuji, Mayumi
Kawamoto, Toshihiro
[J]. BIOMARKERS, 2012, 17 (06) : 575 - 575
[2] Formation of N2-ethylidene-dG adduct in aldehyde dehydrogenase 2 knockout mice due to ethanol drinking
Yu, H.
Oyama, T.
Matsuda, T.
Isse, T.
Tanaka, M.
Kawamoto, T.
[J]. TOXICOLOGY LETTERS, 2011, 205 : S83 - S83
[3] Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol
Matsuda, Tomonari
Matsumoto, Akiko
Uchida, Mitsuhiro
Kanaly, Robert A.
Misaki, Kentaro
Shibutani, Shinya
Kawamoto, Toshihiro
Kitagawa, Kyoko
Nakayama, Keiichi I.
Tomokuni, Katsumaro
Ichiba, Masayoshi
[J]. CARCINOGENESIS, 2007, 28 (11) : 2363 - 2366
[4] Increased formation of gastric N2-ethylidene-2′-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol
Nagayoshi, Haruna
Matsumoto, Akiko
Nishi, Ryuhei
Kawamoto, Toshihiro
Ichiba, Masayoshi
Matsuda, Tomonari
[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2009, 673 (01) : 74 - 77
[5] Polyamines facilitate the formation of the mutagenic DNA adduct 1,N2-PropanodG from acetaldehyde and DNA:: Implications for the mechanism of alcohol-related carcinogenesis
Theruvathu, JA
Nath, RG
Brooks, PJ
[J]. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2004, 44 (03) : 231 - 231

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