Pitx2: a left-right asymmetric signalling molecule

被引：0
|
作者：
Liu, JL
Tan, Y
机构：
[1] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100080, Peoples R China
[2] WBL Peking Univ Biotech Co Ltd, Beijing 100080, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 1999年 / 26卷 / 01期
关键词：
left-right asymmetry; Pitx2; vertebrate;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pitx2 is asymmetrically expressed in the left lateral plate mesoderm and derived organs such as heart and gut during chick, mouse and Xenopus development. Pitx2 appears to be downstream effector of Shh and Nodal. Misexpression of Pitx2 is sufficient to produce reversed organs of body rotation. Defect of Pitx2 in human may cause Rieger syndrome. Pitx2 seems to be a key conserved signalling molecules that mediates left-right asymmetry in vertebrate.
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页码：3 / 5
页数：3
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