Sirolimus plus sorafenib in treating HCC recurrence after liver transplantation: A case report

被引：23
|
作者：
Wang, Yubao [1 ]
Speeg, Kermit V. [2 ]
Washburn, William Kenneth [2 ]
Half, Glenn [2 ]
机构：
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Hematol & Med Oncol, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Transplant Ctr, San Antonio, TX 78229 USA
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 43期
关键词：
Hepatocellular carcinoma; Liver transplantation; Mammalian target of rapamycin inhibitor; Sirolimus; Sorafenib; RENAL-CELL CARCINOMA; HEPATOCELLULAR-CARCINOMA; MAMMALIAN TARGET; THERAPY; EXPERIENCE; INHIBITOR; PATHWAY; GROWTH; MODELS;
D O I：
10.3748/wjg.v16.i43.5518
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
A case of hepatocellular carcinoma (HCC) with pulmonary recurrence after liver transplantation for HCC is presented in this report. The patient showed disease progression on sorafenib therapy demonstrated by computed tomography scans as well as serial serum a-fetoprotein (AFP) elevation. After his immunosuppression therapy was successfully transitioned to sirolimus and a continuation of sorafenib, he achieved partial remission based on RECIST criteria and normalization of AFP. Mammalian target of rapamycin inhibitors including sirolimus alone or in conjunction with sorafenib may be useful in the treatment of post transplant HCC. (C) 2010 Baishideng. All rights reserved.
引用
收藏
页码：5518 / 5522
页数：5
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