Targeting inducible nitric oxide in a first-in-class phase 1/2 trial in triple-negative breast cancer patients diminishes M2 macrophage polarization and led to a robust clinical response.

被引：0

作者：

Chung, Andrew W. ^{[1
]}

Anand, Kartik ^{[2
]}

Niravath, Polly ^{[3
]}

Gupta, Nakul ^{[3
]}

Venta, Luz A. ^{[3
]}

Schwartz, Mary R. ^{[3
]}

Qian, Wei ^{[3
]}

Xu, Yitian ^{[3
]}

Zhang, Licheng ^{[3
]}

Chen, Qiuying ^{[4
]}

Attarwala, Nabeel ^{[4
]}

Kuhn, John ^{[5
]}

Patel, Tejal A. ^{[6
]}

Rodriguez, Angel ^{[7
]}

Belcheva, Anna ^{[3
]}

Darcourt, Jorge ^{[3
]}

Ensor, Joe E. ^{[3
]}

Bernicker, Eric ^{[3
]}

Pan, Ping-Ying ^{[3
]}

Kaklamani, Virginia ^{[5
]}

Chen, Shu-Hsia ^{[3
]}

Chang, Jenny C. ^{[3
]}

机构：

[1] Texas A&M Univ, Houston, TX USA

[2] Great Plains Hlth, North Platte, NE USA

[3] Houston Methodist Canc Ctr, Houston, TX USA

[4] Weill Cornell Med, New York, NY USA

[5] Univ Texas, Hlth Sci Ctr San Antonio, San Antonio, TX USA

[6] MD Anderson Canc Ctr, Houston, TX USA

[7] Austin Canc Ctr, Austin, TX USA

来源：

CANCER RESEARCH | 2021年 / 81卷 / 13期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CT175

引用

页数：2

共 42 条

[1] Phase 1B/2 clinical trial targeting nitric oxide in the treatment of chemo-refractory metaplastic triple-negative breast cancer patients
Puri, Akshjot
Ordonez, Adriana
Anselme, Ann C.
Guzman, Liliana
Niravath, Polly
Chang, Jenny C.
CANCER RESEARCH, 2022, 82 (04)
[2] TRIM21-mediated Sohlh2 ubiquitination suppresses M2 macrophage polarization and progression of triple-negative breast cancer
Ruihong Zhang
Ying Shen
Qi Zhang
Xiaoning Feng
Xuyue Liu
Xiaoning Huo
Jinhao Sun
Jing Hao
Cell Death & Disease, 14
[3] TRIM21-mediated Sohlh2 ubiquitination suppresses M2 macrophage polarization and progression of triple-negative breast cancer
Zhang, Ruihong
Shen, Ying
Zhang, Qi
Feng, Xiaoning
Liu, Xuyue
Huo, Xiaoning
Sun, Jinhao
Hao, Jing
CELL DEATH & DISEASE, 2023, 14 (12)
[4] Triple-negative breast cancer influences a mixed M1/M2 macrophage phenotype associated with tumor aggressiveness
Pe, Kristine Cate S.
Saetung, Rattana
Yodsurang, Varalee
Chaotham, Chatchai
Suppipat, Koramit
Chanvorachote, Pithi
Tawinwung, Supannikar
PLOS ONE, 2022, 17 (08):
[5] A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer
Chung, Andrew W.
Anand, Kartik
Anselme, Ann C.
Chan, Alfred A.
Gupta, Nakul
Venta, Luz A.
Schwartz, Mary R.
Qian, Wei
Xu, Yitian
Zhang, Licheng
Kuhn, John
Patel, Tejal
Rodriguez, Angel A.
Belcheva, Anna
Darcourt, Jorge
Ensor, Joe
Bernicker, Eric
Pan, Ping-Ying
Chen, Shu Hsia
Lee, Delphine J.
Niravath, Polly A.
Chang, Jenny C.
SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (624)
[6] SPP1 mRNA Expression Is Associated with M2 Macrophage Infiltration and Poor Prognosis in Triple-Negative Breast Cancer
Chen, Yu-Chia
Chen, Chia-Ching
Chen, Rong-Fu
Chen, Hsin-Hung
Chen, Po-Ming
CURRENT ISSUES IN MOLECULAR BIOLOGY, 2024, 46 (12) : 13499 - 13513
[7] OTUD5-mediated deubiquitination of YAP in macrophage promotes M2 phenotype polarization and favors triple-negative breast cancer progression
Zhang, Yujiao
Fan, Yizeng
Jing, Xin
Zhao, Lin
Liu, Tianjie
Wang, Lu
Zhang, Lifen
Gu, Shanzhi
Zhao, Xinhan
Teng, Yan
CANCER LETTERS, 2021, 504 : 104 - 115
[8] SPI1-mediated transcriptional activation of CEP55 promotes the malignant growth of triple-negative breast cancer and M2 macrophage polarization
Liu, Yuanwei
Dong, Ming
Jia, Yong
Yang, Dezhen
Hui, Yang
Yang, Xiaodong
PATHOLOGY RESEARCH AND PRACTICE, 2024, 262
[9] Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress
Al Haq, Aushia Tanzih
Tseng, Hong-Yu
Chen, Li-Mei
Wang, Chien-Chia
Hsu, Hsin-Ling
CELL DEATH & DISEASE, 2022, 13 (01)
[10] Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress
Aushia Tanzih Al Haq
Hong-Yu Tseng
Li-Mei Chen
Chien-Chia Wang
Hsin-Ling Hsu
Cell Death & Disease, 13

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