miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5

被引：134
|
作者：
Miko, Edit [1 ]
Margitai, Zoltan [2 ]
Czimmerer, Zsolt [1 ]
Varkonyi, Ildiko [3 ]
Balazs Dezso [3 ]
Lanyi, Arpad [4 ]
Bacso, Zsolt [2 ]
Scholtz, Beata [1 ]
机构：
[1] UDMHSC, Clin Genom Ctr, Dept Biochem & Mol Biol, H-4010 Debrecen, Hungary
[2] UDMHSC, Dept Biophys & Cell Biol, H-4010 Debrecen, Hungary
[3] UDMHSC, Dept Pathol, H-4010 Debrecen, Hungary
[4] UDMHSC, Inst Immunol, H-4010 Debrecen, Hungary
来源：
FEBS LETTERS | 2011年 / 585卷 / 08期
基金：
匈牙利科学研究基金会;
关键词：
Small cell lung cancer; miR-126; SLC7A5; G1; delay; PROTEIN-KINASE-B; VASCULAR INTEGRITY; EXPRESSION; GROWTH; 3-KINASE; LAT1; MICRORNAS; TUMORS; MIRNA; MTOR;
D O I：
10.1016/j.febslet.2011.03.039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Despite intensive efforts to improve therapies, small cell lung cancer (SCLC) still has a dismal median survival of 18 months. Since miR-126 is under-expressed in the majority of SCLC tumors, we investigated the effect of miR-126 overexpression on the proliferation and cell cycle distribution of H69 cells. Our results demonstrate that miR-126 inhibits proliferation of H69 cells, by delaying the cells in the G1 phase. Short interfering RNA (siRNA) mediated suppression of SLC7A5, a predicted target of mir-126, has the same effect on H69 cells. We also show for the first time that SLC7A5 is a direct target of miR-126. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：1191 / 1196
页数：6
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