Benzoxazine isoquinolines as M4 selective muscarinic receptor antagonists

被引:0
|
作者
Schwarz, RD
Boehme, TM
Augelli-Szafran, CE
Moreland, DW
机构
[1] Pfizer Global Res & Dev, Ann Arbor Labs, Dept Neurosci Therapeut, Ann Arbor, MI USA
[2] Pfizer Global Res & Dev, Ann Arbor Labs, Dept Med Chem, Ann Arbor, MI USA
关键词
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
23
引用
收藏
页码:2626 / 2626
页数:1
相关论文
共 50 条
  • [1] Benzoxazine isoquinoline as m4 selective muscarinic receptor antagonists.
    Boehme, TM
    Augelli-Szafran, CE
    Moreland, DW
    Schwarz, RD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U565 - U565
  • [2] Identification and characterization of m4 selective muscarinic antagonists
    Augelli-Szafran, CE
    Jaen, JC
    Moreland, DW
    Nelson, CB
    Penvose-Yi, JR
    Schwarz, RD
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (15) : 1991 - 1996
  • [3] Identification and characterization of m4 selective muscarinic antagonists
    AugelliSzafran, CE
    Moreland, DW
    Nelson, CB
    PenvoseYi, JR
    Schwarz, RD
    Jean, JC
    LIFE SCIENCES, 1997, 60 (13-14) : 11 - 11
  • [4] SELECTIVE LABELING AND LOCALIZATION OF THE M4 (M4) MUSCARINIC RECEPTOR SUBTYPE
    FERRARIDILEO, G
    WAELBROECK, M
    MASH, DC
    FLYNN, DD
    MOLECULAR PHARMACOLOGY, 1994, 46 (06) : 1028 - 1035
  • [5] Analogs of M4 selective synthetic muscarinic receptor antagonists:: Synthesis, binding and pharmacokinetic properties
    Böhme, TM
    Augelli-Szafran, CE
    Hallak, H
    Schwarz, RD
    MEDICINAL CHEMISTRY RESEARCH, 2002, 11 (08) : 423 - 433
  • [6] Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy
    Moehle, Mark S.
    Bender, Aaron M.
    Dickerson, Jonathan W.
    Foster, Daniel J.
    Qi, Aidong
    Cho, Hyekyung P.
    Donsante, Yuping
    Peng, Weimin
    Bryant, Zoey
    Stillwell, Kaylee J.
    Bridges, Thomas M.
    Chang, Sichen
    Watson, Katherine J.
    O'Neill, Jordan C.
    Engers, Julie L.
    Peng, Li
    Rodriguez, Alice L.
    Niswender, Colleen M.
    Lindsley, Craig W.
    Hess, Ellen J.
    Conn, P. Jeffrey
    Rook, Jerri M.
    ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2021, 4 (04) : 1306 - 1321
  • [7] Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors
    Böhme, TM
    Augelli-Szafran, CE
    Hallak, H
    Pugsley, T
    Serpa, K
    Schwarz, RD
    JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (14) : 3094 - 3102
  • [8] Diphenidol-related diamines as novel muscarinic M4 receptor antagonists
    Varoli, Lucilla
    Andreani, Aldo
    Burnelli, Silvia
    Granaiola, Massimiliano
    Leoni, Alberto
    Locatelli, Alessandra
    Morigi, Rita
    Rambaldi, Mirella
    Bedini, Andrea
    Fazio, Nicola
    Spampinato, Santi
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (09) : 2972 - 2976
  • [9] BINDING OF SELECTIVE ANTAGONISTS TO 4 MUSCARINIC RECEPTORS (M1 TO M4) IN RAT FOREBRAIN
    WAELBROECK, M
    TASTENOY, M
    CAMUS, J
    CHRISTOPHE, J
    MOLECULAR PHARMACOLOGY, 1990, 38 (02) : 267 - 273
  • [10] Role of M1 and M4 receptors in development of myopia:: Study with muscarinic receptor antagonists and muscarinic toxins
    Diether, S
    Schaeffel, F
    Fritsch, C
    Trendelenburg, AU
    Payor, R
    Lambrou, GN
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46