Non-alcoholic fatty liver disease and the impact of genetic, epigenetic and environmental factors in the offspring

被引：8
|
作者：
Wajsbrot, Natalia Balassiano [1 ]
Leite, Nathalie Carvalho [1 ]
Salles, Gil F. [2 ]
Villela-Nogueira, Cristiane A. [2 ,3 ]
机构：
[1] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Div Hepatol, BR-20941913 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Med Sch, Dept Internal Med, BR-22750240 Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Med Sch, Dept Internal Med, Rua Prof Rodolpho Paulo Rocco,255 Room 9E16, BR-22750240 Rio De Janeiro, Brazil
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2022年 / 28卷 / 25期
关键词：
Steatosis; Genetic; Epigenetic; Environmental; Offspring; Non-alcoholic fatty liver disease; MATERNAL OBESITY; CONFERS SUSCEPTIBILITY; VARIANT; RISK; ADIPOSITY; PROGRAMS; PNPLA3; HERITABILITY; ASSOCIATION; STEATOSIS;
D O I：
10.3748/wjg.v28.i25.2890
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is strongly associated with metabolic deregulation. More recently, a significant impact of parental NAFLD in the offspring was demonstrated and has been widely discussed. However, pathogenetic pathways implicated in the inheritance by the offspring and relatives are still under debate. Probably, multiple mechanisms are involved as well as in NAFLD pathogenesis itself. Among the multifactorial involved mechanisms, genetic, epigenetic and environmental backgrounds are strongly related to NAFLD development in the offspring. Thus, based on recent evidence from the available literature concerning genetic, epigenetic and environmental disease modifiers, this review aimed to discuss the relationship between parental NAFLD and its impact on the offspring.
引用
收藏
页码：2890 / 2899
页数：10
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