Synthesis of some oxazolo[4,5-d]pyrimidine derivatives and evaluation of their antiviral activity and cytotoxicity

被引：0

作者：

Velihina, Yevheniia ^{[1
]}

Pil'o, Stepan ^{[1
]}

Kobzar, Oleksandr ^{[1
]}

Zaliavska, Olena ^{[2
]}

Prichard, Mark N. ^{[3
]}

James, Scott H. ^{[3
]}

Keith, Kathy ^{[3
]}

Hartline, Caroll ^{[3
]}

Zhirnov, Victor ^{[1
]}

Vovk, Andriy ^{[1
]}

Brovarets, Volodymyr ^{[1
]}

机构：

[1] NAS Ukraine, VP Kukhar Inst Bioorgan Chem & Petrochem, 1 Murmanska St, UA-02094 Kiev, Ukraine

[2] Bukovinian State Med Univ, Dept Internal Med Clin Pharmacol & Occupat Dis, 2 Sq Teatralna, UA-58002 Chernovtsy, Ukraine

[3] Univ Alabama Birmingham, Div Pediat Infect Dis, Dept Pediat, Birmingham, AL 35233 USA

来源：

ARKIVOC | 2022年

基金：

美国国家卫生研究院; 新加坡国家研究基金会;

关键词：

Oxazolo[4; d ]pyrimidine derivatives; synthesis; antiviral activity; cytotoxicity; STANDARDIZED APPROACH;

D O I：

10.24820/ark.5550190.p011.693

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New oxazolo[4,5-d]pyrimidine derivatives were synthesized and their some physicochemical and ADMET properties were analyzed by in silico prediction. Antiviral activity against DNA viruses (human cytomegalovirus, varicella-zoster virus, herpes simplex virus and BK virus) and cytotoxicity, including control experiments, were evaluated in vitro. Some of the compounds synthesized were characterized by low toxicity; however, they did not exhibit favorable antiviral effects.

引用

页码：108 / 117

页数：10

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