IL-12 and viral infections

被引：54
|
作者：
Komatsu, T
Ireland, DDC
Reiss, CS
机构：
[1] NYU, Dept Biol, New York, NY 10003 USA
[2] NYU, Ctr Neural Sci, New York, NY 10003 USA
[3] NYU, Kaplan Comprehens Canc Ctr, New York, NY 10003 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 1998年 / 9卷 / 3-4期
关键词：
interleukin-12; viral infection; signal transduction; innate immunity; acquired immunity;
D O I：
10.1016/S1359-6101(98)00017-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs. Experimental studies have shown that administration of the cytokine rapidly activates both innate and specific immune responses; this results in enhanced host cellular responses and generally, promotes clearance of virus and host recovery from infection. The observations of many laboratories, studying viral immunity to both RNA and DNA based pathogens, are summarized. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：277 / 285
页数：9
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