Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype

被引：45
|
作者：
Tsuji, Brian T. [1 ,2 ,3 ,4 ]
von Eiff, Christof [5 ]
Kelchlin, Pamela A. [1 ,2 ]
Forrest, Alan [1 ,2 ]
Smith, Patrick F. [1 ,2 ,3 ,4 ]
机构：
[1] SUNY Buffalo, Sch Pharm & Pharmaceut Sci, Lab Antimicrobial Pharmacodynam, Buffalo, NY 14260 USA
[2] SUNY Buffalo, New York State Ctr Excellence Bioinformat & Life, Buffalo, NY 14260 USA
[3] Roswell Pk Canc Inst, Dept Pharm, Buffalo, NY 14260 USA
[4] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14260 USA
[5] Univ Munster, Inst Med Microbiol, Munster, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 04期
关键词：
D O I：
10.1128/AAC.01254-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.
引用
收藏
页码：1533 / 1537
页数：5
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