An exception to the normal Mitsunobu reaction with phenols; the formation of hydrazones from salicylaldehydes

被引：27
|
作者：
Girard, M
Murphy, P
Tsou, NN
机构：
[1] Merck Frosst Canada & Co, Dept Med Chem, Pointe Claire, PQ H9R 4P8, Canada
[2] Merck Res Labs, Rahway, NJ 07065 USA
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 14期
关键词：
Mitsunobu; hydrazone; salicylaldehyde;
D O I：
10.1016/j.tetlet.2005.02.051
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 2-hydroxybenzaldehydes with alkanols in the presence of triphenylphosphine and di-tert-butyl azodicarboxylate (DBAD), under the Mitsunobu reaction conditions, gives rise to the formation of hydrazones as the major products rather than the expected alkyl aryl ethers. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2449 / 2452
页数：4
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