The In Situ Sulfidation of Cu2O by Endogenous H2S for Colon Cancer Theranostics

被引：178
|
作者：
An, Lu [1 ,2 ]
Wang, Xiaodong [1 ,2 ]
Rui, Xichuan [1 ,2 ]
Lin, Jiaomin [1 ,2 ]
Yang, Hong [1 ,2 ]
Tian, Qiwei [1 ,2 ]
Tao, Cheng [1 ,2 ]
Yang, Shiping [1 ,2 ]
机构：
[1] Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Minist Educ, Key Lab Resource Chem, Shanghai 200234, Peoples R China
[2] Shanghai Normal Univ, Shanghai Municipal Educ Comm Key Lab Mol Imaging, Shanghai 200234, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 48期
基金：
中国国家自然科学基金;
关键词：
colon cancer; cuprous oxide; endogenous H2S; in situ reactions; theranostics; HYDROGEN-SULFIDE; PROBES; CELLS;
D O I：
10.1002/anie.201810082
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Expression of a high concentration of H2S is closely related to the formation of colon cancer tumors. However, only a few H2S-triggered theranostics agents for colon cancer have been reported to date. Now, a turn-on theranostics agent was developed by utilizing the in situ reaction of Cu2O and endogenous H2S at colon tumor sites. Based on in vitro and in vivo experiments, excellent photoacoustic imaging and photothermal therapy were both confirmed by this in situ reaction-activated colon cancer theranostics method. This work established a simple and efficient strategy for both diagnosis and treatment of colon cancer with a novel trigger mechanism, which provides a new route for colon cancer theranostics based on the in situ reactions at the tumor sites.
引用
收藏
页码：15782 / 15786
页数：5
相关论文
共 50 条
  • [1] A theoretical study of the H2O and H2S chemisorption on Cu2O(111)
    Casarin, M
    Maccato, C
    Vigato, N
    Vittadini, A
    APPLIED SURFACE SCIENCE, 1999, 142 (1-4) : 164 - 168
  • [2] Synthesis of Cu2O/CuO Nanocrystals and Their Application to H2S Sensing
    Mikami, Kazuki
    Kido, Yuta
    Akaishi, Yuji
    Quitain, Armando
    Kida, Tetsuya
    SENSORS, 2019, 19 (01)
  • [3] Electroactive Cu2O nanocubes engineered electrochemical sensor for H2S detection
    Gu, Wenxiu
    Zheng, Wangwang
    Liu, Han
    Zhao, Yuan
    ANALYTICA CHIMICA ACTA, 2021, 1150
  • [4] Oral Exhalation H2S Sensor Based on Cu2O/ZnO Heterostructures
    Chen, Huijuan
    Lv, Li
    Xue, Kaifeng
    Zhang, Pinhua
    Du, Lulu
    Cui, Guangliang
    ACS SENSORS, 2025,
  • [5] XPS AND ISS STUDIES ON THE INTERACTION OF H2S WITH POLYCRYSTALLINE CU, CU2O AND CUO SURFACES
    GALTAYRIES, A
    BONNELLE, JP
    SURFACE AND INTERFACE ANALYSIS, 1995, 23 (03) : 171 - 179
  • [6] Remodeling endogenous H2S microenvironment in colon cancer to enhance chemodynamic therapy
    Liu, Donglin
    Liu, Mengjun
    Wan, Ying
    Zhou, Xuesu
    Yang, Shiping
    An, Lu
    Huang, Gang
    Tian, Qiwei
    CHEMICAL ENGINEERING JOURNAL, 2021, 422
  • [7] 2D electrodeposition assembly of Cu/Cu2O nanoarrays for low temperature H2S sensing
    Chen, Huijuan
    Gao, Fangrui
    Ren, Wenbin
    Du, Lulu
    Xue, Kaifeng
    Zhang, Pinhua
    Shi, Changmin
    Lv, Li
    Cui, Guangliang
    APPLIED SURFACE SCIENCE, 2025, 679
  • [8] H2S Adsorption Characteristics on Cu2O Nanostructures: A First-Principles Study
    V. Nagarajan
    R. Chandiramouli
    Journal of Inorganic and Organometallic Polymers and Materials, 2015, 25 : 1529 - 1541
  • [9] H2S Adsorption Characteristics on Cu2O Nanostructures: A First-Principles Study
    Nagarajan, V.
    Chandiramouli, R.
    JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2015, 25 (06) : 1529 - 1541
  • [10] In Situ Monitoring of H2-Induced Nonstoichiometry in Cu2O
    Wang, Jianyu
    Li, Chaoran
    Zhu, Yaguang
    Boscoboinik, Jorge Anibal
    Zhou, Guangwen
    JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2022, 13 (24): : 5597 - 5604
12345