Pd-NHC catalyzed Suzuki cross-coupling of benzyl ammonium salts

被引：4
|
作者：
Zhong, Chuntao [1 ]
Tang, Huiling [1 ]
Cui, Benqiang [1 ]
Shi, Yanhui [1 ]
Cao, Changsheng [1 ]
机构：
[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2022年 / 48卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Suzuki reaction; Quaternary ammonium salts; Palladium NHC; Diarylmethanes; C-N BOND; BENZYLTRIMETHYLAMMONIUM SALTS; ARYL; DIARYLMETHANES; ACIDS; ACTIVATION; HYDROGENATION; ALKYLARENES; COMPLEXES; ARYLATION;
D O I：
10.1007/s11164-022-04795-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium-catalyzed Suzuki cross-coupling of benzyl ammonium triflates via activation of a Csp(3)-N bond to construct a Csp(3)-Csp(2) bond is described. Various boronic acids can be coupled with a range of benzylamine-derived quaternary ammonium salts in 1:1 molar ratio by the bench-stable N-heterocyclic carbene palladium complex, SIPr-PdCl2-Py to afford diarylmethane derivatives. This reaction exhibits a wide substrate scope and functional group tolerance. Direct arylation of benzylamine in a one-pot process and the gram-scale reaction can be performed successfully.
引用
收藏
页码：4017 / 4032
页数：16
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