Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection

被引：220
|
作者：
Lafeuillade, A [1 ]
Hittinger, G [1 ]
Chadapaud, S [1 ]
机构：
[1] Hop Chalucet, Dept Infect Dis, Toulon, France
来源：
LANCET | 2001年 / 357卷 / 9252期
关键词：
D O I：
10.1016/S0140-6736(00)03618-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-alpha plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.
引用
收藏
页码：280 / 281
页数：2
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