DNA-catalysed alternative RNA splicing

被引：0

作者：

Wei, Dongying ^{[1
]}

Gao, Mingmei ^{[1
]}

Guo, Jiajie ^{[1
]}

Wang, Yueyao ^{[1
]}

Li, Xintong ^{[2
]}

Li, Zhe ^{[3
]}

Yu, Hanyang ^{[1
]}

机构：

[1] Nanjing Univ, Dept Biomed Engn, Coll Engn & Appl Sci,State Key Lab Coordinat Chem, Chem & Biomed Innovat Ctr ChemBIC,Jiangsu Key Lab, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, Nanjing 210023, Jiangsu, Peoples R China

[3] Nanjing Univ, Coll Engn & Appl Sci, Dept Biomed Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 55期

关键词：

ZN2+-DEPENDENT DEOXYRIBOZYMES; SITE-SELECTIVITY; PYRIMIDINE; INSIGHT; INTRON;

D O I：

10.1039/d2cc00812b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report DNA-catalysed alternative RNA splicing in vitro. Using modular DNA catalysts with RNA endonuclease and RNA ligase activities, we show that DNA can modulate RNA structure and activity. Furthermore, we illustrate that such DNA-catalysed reactions can yield, from a common precursor, different splicing isoforms with distinct functions.

引用

页码：7698 / 7701

页数：4

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