The Role of Galectin-3 and ST2 in Cardiology: A Short Review

被引：21
|
作者：
Merino-Merino, Ana [1 ]
Gonzalez-Bernal, Jeronimo [2 ]
Fernandez-Zoppino, Dario [2 ,3 ]
Saez-Maleta, Ruth [4 ]
Perez-Rivera, Jose-Angel [1 ]
机构：
[1] Univ Hosp Burgos, Dept Cardiol, Burgos 09005, Spain
[2] Univ Burgos, Dept Hlth Sci, Burgos 09005, Spain
[3] Natl Sci & Tech Res Council CONICET, RA-2290 Buenos Aires, DF, Argentina
[4] Univ Hosp Burgos, Dept Clin Anal, Burgos 09005, Spain
来源：
BIOMOLECULES | 2021年 / 11卷 / 08期
关键词：
ST2; galectin-3; biomarkers; cardiology; HEART-FAILURE; ATRIAL-FIBRILLATION; SOLUBLE ST2; PROGNOSTIC VALUE; NATRIURETIC PEPTIDE; RISK STRATIFICATION; SERIAL MEASUREMENTS; CATHETER ABLATION; RENAL-FUNCTION; BIOMARKERS;
D O I：
10.3390/biom11081167
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Galectin-3 is a lectin that binds beta-galactosides. It is involved in cardiac remodeling and fibrosis through the activation of macrophages and fibroblasts. ST2 is secreted by myocardial cells due to cardiac overload. These two biomarkers have been traditionally studied in the field of heart failure to guide medical therapy and detect the progression of the disease. Nevertheless, there are novel evidences that connect galectin-3 and ST2 with coronary heart disease and, specifically, with atrial fibrillation. The aim of this article is to concisely review the diagnostic and prognostic role of galectin-3 and ST2 in different cardiac diseases.
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页数：9
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