Rapid detection of lamotrigine by a water stable fluorescent lanthanide metal-organic framework sensor

被引:9
|
作者
Ma, Yunxiao [1 ,2 ]
Zhao, Zhongqiu [1 ,2 ]
Zhu, Mingchang [1 ,2 ]
Zhang, Ying [1 ,2 ]
Kosinova, Marina [4 ]
Fedin, Vladimir P. [4 ]
Wu, Shuangyan [1 ,2 ]
Gao, Enjun [1 ,2 ,3 ]
机构
[1] Shenyang Univ Chem Technol, Key Lab Inorgan Mol Based Chem Liaoning Prov, 11th St, Shenyang 110142, Liaoning, Peoples R China
[2] Shenyang Univ Chem Technol, Lab Coordinat Chem, 11th St, Shenyang 110142, Liaoning, Peoples R China
[3] Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan 114051, Liaoning, Peoples R China
[4] Russian Acad Sci, Nikolaev Inst Inorgan Chem, Lavrentiev Ave 3, Novosibirsk 630090, Russia
关键词
Tb-MOF; Ratio; Lamotrigine (LTG); Epilepsy; Fluorescent detection; STEVENS-JOHNSON-SYNDROME; SOLID-PHASE EXTRACTION; SELECTIVE DETECTION; HUMAN PLASMA; COORDINATION POLYMERS; ANTIDEPRESSANT DRUGS; ANTIEPILEPTIC DRUGS; LUMINESCENT SENSOR; MASS-SPECTROMETRY; NORTRIPTYLINE;
D O I
10.1016/j.poly.2022.115803
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Lamotrigine (LTG) is an antiepileptic drug, but excessive use of LTG can cause life-threatening skin rashes. Herein, a new type of Tb-MOF with two emitting centers for LTG detection was designed and synthesized. The unique crystal structure is derived from a hexacarboxylic acid ligand and lanthanide Tb3+ ion. The application of ratiometric fluorescence sensing improves the accuracy for detecting LTG. The Tb-MOF also displays excellent sensitivity with fast response within 40 s, low detection limit of 1.66 mu M and high recyclability. This research provides important significance for using lanthanide metal-organic framework (Ln-MOF) as the platform for fluorescent sensing.
引用
收藏
页数:6
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