Cobalt-Catalyzed Cross-Coupling of α-Bromo Amides with Grignard Reagents

被引：20
|
作者：
Barde, E. [1 ]
Guerinot, A. [1 ]
Cossy, J. [1 ]
机构：
[1] PSL Res Univ, Lab Chim Organ, Inst Chem Biol & Innovat CBI, ESPCI Paris,CNRS,UMR 8231, 10 Rue Vauquelin, F-75231 Paris 05, France
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 22期
关键词：
5-ENDO-TRIG RADICAL CYCLIZATION; C-H BONDS; ALKYL-HALIDES; ARYL HALIDES; BETA; GAMMA-UNSATURATED AMIDES; 6-HALO-1-HEXENE DERIVATIVES; HALOCARBONYL COMPOUNDS; NEUTRAL CONDITIONS; CARBONYL-COMPOUNDS; ARYLBORONIC ACIDS;
D O I：
10.1021/acs.orglett.7b02848
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A cobalt-catalyzed cross-coupling between alpha-bromo amides and Grignard reagents is disclosed. The reaction is general and allows access to a large variety of alpha-aryl and beta,gamma-unsaturated amides. Some mechanistic investigations have been undertaken to determine the nature of the intermediate species.
引用
收藏
页码：6068 / 6071
页数：4
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