ROR1 expression is not a unique marker of CLL

被引：56
|
作者：
Barna, Gabor [1 ]
Mihalik, Rudolf [1 ,2 ]
Timar, Botond [1 ]
Toemboel, Judit [1 ]
Csende, Zsolt [3 ]
Sebestyen, Anna [1 ]
Boedoer, Csaba [1 ]
Csernus, Balazs [1 ]
Reiniger, Lilla [1 ]
Petak, Istvan [1 ,2 ]
Matolcsy, Andras [1 ]
机构：
[1] Semmelweis Univ, Fac Med, Dept Pathol & Expt Canc Res 1, H-1085 Budapest, Hungary
[2] Semmelweis Univ, Cooperat Res Ctr, H-1085 Budapest, Hungary
[3] Fac Med, Dept Biomech, Budapest, Hungary
来源：
HEMATOLOGICAL ONCOLOGY | 2011年 / 29卷 / 01期
关键词：
CLL; MCL; MZL; ROR1; Wnt; lymphoma; CHRONIC LYMPHOCYTIC-LEUKEMIA; RECEPTOR TYROSINE KINASE; GENE-EXPRESSION; HUMAN CANCER; B-CELLS; MUTATIONS; SCREEN; PROGRESSION; ACTIVATION; PHENOTYPE;
D O I：
10.1002/hon.948
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent studies have identified receptor tyrosine kinase-like orphan receptor 1 (ROR1) on the surface of chronic lymphoid leukaemia (CLL) cells. In order to determine whether ROR1 expression is a suitable surrogate marker for the diagnosis of CLL we analysed the mRNA level of ROR1 in different types of non-Hodgkin lymphomas (NHL), and detected elevated levels of ROR1 compared to control peripheral mononuclear cells in several entities (CLL >= mantle cell lymphoma (MCL) > marginal zone lymphoma (MZL)>> diffuse large B-cell lymphoma > follicular lymphoma). ROR1 protein was expressed intensely on the cell surface of lymphoma cells with leukaemic blood count detected by three colour immunofluorescence. Our results indicate that ROR1 expression is not limited to CLL cases, but it is more prevalent in NHLs, mainly in MCL where it is expressed intensely and MZL where it is expressed moderately, suggesting a general role of ROR1 in lymphoma genesis and/or maintenance. Copyright (C) 2010 John Wiley & Sons, Ltd.
引用
收藏
页码：17 / 21
页数：5
相关论文
共 50 条
  • [1] ROR1 EXPRESSION IS NOT A UNIQUE MARKER OF CLL
    Barna, Gabor
    Mihalik, Rudolf
    Timar, Botond
    Csende, Zsolt
    Sebestyen, Anna
    Toemboel, Judit
    Boedoer, Csaba
    Csernus, Balazs
    Matolcsy, Andras
    CYTOMETRY PART B-CLINICAL CYTOMETRY, 2010, 78B (06) : 436 - 436
  • [2] TREATMENT WITH BCR INHIBITORS INCREASES ROR1 EXPRESSION IN CLL CELLS
    Kotaskova, J.
    Pavlova, S.
    Plevova, K.
    Malcikova, J.
    Stehlikova, O.
    Poppova, L.
    Kockova, H.
    Doubek, M.
    Bryja, V.
    Pospisilova, S.
    HAEMATOLOGICA, 2017, 102 : 414 - 414
  • [3] ROR1 and ROR2 expression in pancreatic cancer
    Dongli Liu
    George Sharbeen
    Phoebe Phillips
    Caroline E. Ford
    BMC Cancer, 21
  • [4] Molecular mechanism regulating expression of Ror1 in GSCs and the role of Ror1 in maintaining their stemness
    Ishikawa, Tomohiro
    Endo, Mitsuharu
    Tanaka, Kazuhiro
    Nagashima, Hiroaki
    Sasayama, Takashi
    Minami, Yasuhiro
    CANCER SCIENCE, 2023, 114 : 1141 - 1141
  • [5] ROR1 and ROR2 expression in pancreatic cancer
    Liu, Dongli
    Sharbeen, George
    Phillips, Phoebe
    Ford, Caroline E.
    BMC CANCER, 2021, 21 (01)
  • [6] Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells
    Choudhury, Aniruddha
    Derkow, Katja
    Daneshmanesh, Amir Hossein
    Mikaelsson, Eva
    Kiaii, Shahryar
    Kokhaei, Parviz
    Osterborg, Anders
    Mellstedt, Hakan
    BRITISH JOURNAL OF HAEMATOLOGY, 2010, 151 (04) : 327 - 335
  • [7] Does CD5 have an effect on the expression of ROR1 in chronic lymphocytic leukemia (CLL)?
    Alsulami, H.
    Hallek, M.
    Kreuzer, K. A.
    ONKOLOGIE, 2011, 34 : 138 - 139
  • [8] Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) - a Putative Diagnostic Marker for Chronic Lymphocytic Leukemia (CLL).
    Uhrmacher, Sabrina
    Hertweck, Magdalena
    Paesler, Julian
    Erdfelder, Felix
    Filipovich, Alexandra
    Poll-Wolbeck, Simon Jonas
    Razavi, Regina
    Gandhirajan, Rajesh Kumar
    Gehrke, Iris
    Hallek, Michael
    Kreuzer, Karl Anton
    BLOOD, 2009, 114 (22) : 635 - 635
  • [9] Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma
    Chang, Hyeyoon
    Jung, Woon Yong
    Kang, Youngran
    Lee, Hyunjoo
    Kim, Aeree
    Kim, Baek-hui
    ANNALS OF DIAGNOSTIC PATHOLOGY, 2015, 19 (05) : 330 - 334
  • [10] Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
    Dave, Zankruti
    Blanarova, Olga Vondalova
    Cada, Stepan
    Janovska, Pavlina
    Zezula, Nikodem
    Behal, Martin
    Hanakova, Katerina
    Ganji, Sri Ranjani
    Krejci, Pavel
    Gomoryova, Kristina
    Peschelova, Helena
    Smida, Michal
    Zdrahal, Zbynek
    Pavlova, Sarka
    Kotaskova, Jana
    Pospisilova, Sarka
    Bryja, Vitezslav
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
12345