Protection of grape vine against pests and pathogens translates into heavy environmental burden more than 100 kg of toxic chemicals per hectare every year. Limiting factor to ensuring long-term sustainability of plant production are answers to two fundamental questions: WHEN (advisory platform - DSS) and WHAT phytosanitary measures must be taken (NDM - zero toxicity concept). DSS: If we want to reduce the number of phytosanitary interventions and reduce toxicological burden in agrocenosis, but simultaneously guarantee rentability of winegrower's work, it is necessary to enter decision-making process of phytosanitary measures with accurate, up-to-date and comprehensive information that are personalized for given vineyard. Advisory platform VITIPORT brings globally applicable protection for viticulture. Its software is based on original algorithms that integrate key abiotic parameters related with pathogens development. They enter mathematical equations in form of coefficients and thus make Vitiport an unique advisory tool built on causal mathematical models. The platform is built on cutting-edge web technologies: SaaS solution using the CLOUD architecture, fast access to data inputs from satellites and terrestrial radar systems. During the whole vegetation period phytosanitary decision-making process is guided by predictions of infection risks for key pathogens for specific "GPS" of the vineyard. End-user information, received a week ahead, is clear, concise, understandable, but most of all personalized. NDM: Methods of plant protection that have been used for decades are based on following formula: plant crop - pathogen - eradication of the pathogen by chemical and/or biological means. NDM concept changes paradigms of plant protection by initiating defense mechanisms of the plant itself instead of using a direct pesticide intervention to fight pathogens. The preparation of NDM substances is a multi-step process employing the most recent knowledge and processes of quantum physics. Diluted concentrate based on natural atomic matrix of plant antibodies is, prior to its use in vineyard, activated with an ultrasonic generator, thereby providing transfer of information about launching plant's defense mechanisms against specific pathogen into water with specific physical parameters. Activated concentrate is finally diluted in the sprayer tank or irrigation system and such final product is applied in the vineyard. Application of NDM substances in agrocenosis does not result in residual contamination of the environment. NDM is therefore a RESIDUE-FREE phytosanitary product, a kind of "vaccine" that activates immune system of the plant.