LIGNAN DERIVATIVES FROM THE LEAVES NICOTIANA TABACUM AND THEIR ACTIVITIES

被引：65

作者：

Gao, Xuemei ^{[1
,2
]}

Li, Xuesen ^{[1
,2
,3
]}

Yang, Xinzhou ^{[1
,2
]}

Mu, Huaixue ^{[1
,2
]}

Chen, Yongkuan ^{[3
]}

Yang, Guangyu ^{[3
]}

Hu, Qiufen ^{[1
,2
]}

机构：

[1] Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China

[2] Minist Educ, Kunming 650031, Peoples R China

[3] Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Peoples R China

来源：

HETEROCYCLES | 2012年 / 85卷 / 01期

关键词：

Nicotiana tabacum; Norlignan; Anti-HIV-1; Activity; Anti-Tobacco Mosaic Virus Activity; TOBACCO; IDENTIFICATION; CHEMISTRY;

D O I：

10.3987/COM-11-12349

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new lignan derivatives, nicotnorlignan A and nicotlactone A (1, 2), together with two known lignan derivatives (3, 4) were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1-4 were tested for their anti-HIV-1 activity and anti-tobacco mosaic virus activities. The results showed compound 2 has high anti-tobacco mosaic virus activities, and all other compounds have modest anti-HIV-1 activity and anti-tobacco mosaic virus activities.

引用

页码：147 / 153

页数：7

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