The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model

被引：8
|
作者：
Kahng, Jimin [1 ]
Kim, Tae Kwan [2 ]
Chung, Eun Yong [2 ]
Kim, Yee Suk [2 ]
Moon, Jeong Yeon [2 ]
机构：
[1] Catholic Univ Korea, Bucheon St Marys Hosp, Dept Lab Med, Bucheon, South Korea
[2] Bucheon St Marys Hosp, Dept Anaesthesia & Pain Med, Bucheon, Kyunggido, South Korea
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2015年 / 43卷 / 03期
关键词：
Thioctic acid; neuropathy; pain; vincristine; ALPHA-LIPOIC ACID; INDUCED PAINFUL NEUROPATHY; INDUCED PERIPHERAL NEUROPATHY; OXIDATIVE STRESS; MECHANICAL ALLODYNIA; OXALIPLATIN; INVOLVEMENT; MORPHINE; DRUGS;
D O I：
10.1177/0300060515569287
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats. Methods Neuropathy was induced in Sprague-Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180min after treatment. Results Mechanical and cold allodynia were reduced by thioctic acid injection. The duration of effect increased with thioctic acid dose. Conclusion Thioctic acid may be an effective treatment for vincristine-induced neuropathy.
引用
收藏
页码：350 / 355
页数：6
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