The aim of this study was to evaluate the effects of at-home and in-office bleaching agents on esthetic CAD-CAM materials after red wine immersion by measuring their optical properties. Sixty specimens were prepared out of three esthetic CAD-CAM materials: Vita Enamic, Celtra Duo, and Ceresmart (n = 20). All specimens were immersed in a red wine solution, and color measurements were performed. Specimens were randomly divided (n = 10) according to the bleaching procedure (in office, at home), bleaching durations were set to 3 time points, and color measurements were performed. According to the Commission Internationale de l'Eclairage (CIE) L* a* b* parameters, CIEDE2000 color differences (Delta E-00), translucency parameters (TP00), and whiteness index values (Delta WID) after wine staining and after bleaching were calculated. Data were analyzed using the Mann-Whitney U-test, the Kruskal-Wallis test, and a two-way analysis of variance (ANOVA) (alpha = 0.05). Delta E-00, Delta TP00, and Delta WID decreased with an increase in bleaching treatment. Delta E-00 after the final bleaching treatment of in-office bleaching ranged from 1.7 to 2.0, whereas those of in-office treatment ranged from 0.4 to 1.1. All Delta TP00 and Delta WID after the final treatment were below the 50:50% perceptibility thresholds (Delta TP00 < 0.6, and Delta WID < 0.7). Significant differences in Delta E-00, Delta TP00, and Delta WID among esthetic CAD-CAM materials were found between CD and CE. In the present study, color recovery after at-home and in-office bleaching appeared to be material-dependent. In-office bleaching showed more effective recovery comparing to at-home bleaching.
