Active self-organization of microtubules in an inert chamber system

被引：17
|
作者：
Kabir, Arif Md Rashedul [5 ]
Inoue, Daisuke [4 ]
Kakugo, Akira [1 ,2 ]
Sada, Kazuki
Gong, Jian Ping [3 ]
机构：
[1] Hokkaido Univ, Grad Sch Sci, Dept Chem, Kita Ku, Sapporo, Hokkaido 0600810, Japan
[2] Japan Sci & Technol Agcy JST, PRESTO, Saitama, Japan
[3] Hokkaido Univ, Fac Adv Life Sci, Sapporo, Hokkaido, Japan
[4] Hokkaido Univ, Grad Sch Life Sci, Div Biol Sci, Sapporo, Hokkaido 0600810, Japan
[5] Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Sapporo, Hokkaido 0600810, Japan
来源：
POLYMER JOURNAL | 2012年 / 44卷 / 06期
基金：
日本科学技术振兴机构;
关键词：
active self-organization; biomachine; biomolecular motor; kinesin; lifetime; microtubule; UNIDIRECTIONAL TRANSPORT; SLIDING MOVEMENT; MOTOR PROTEIN; POLYMERIZATION; FILAMENTS; DYNAMICS; GROWTH;
D O I：
10.1038/pj.2012.26
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Microtubule-kinesin system is considered as a building block for the construction of artificial biomachines, and active self-organization of microtubules has been used to integrate their structural organization and achieve amplified functions similar to those observed in natural systems. However, the short lifetime of assembled structures has limited their use in organized systems. In the present study, we demonstrated that the use of an inert atmosphere in the self-organization of microtubules allows the assembled structures to remain active for a prolonged period of time (10 times longer). The longer lifetime achieved in the present study will facilitate the development of assembled microtubules for designing biomolecular motor-based efficient artificial biomachines with prolonged lifetimes. Polymer Journal (2012) 44, 607-611; doi:10.1038/pj.2012.26; published online 4 April 2012
引用
收藏
页码：607 / 611
页数：5
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