Sildenafil citrate (Viagra) complexes with bivalent ions

被引：3
|
作者：
Melnikov, P
Cuin, A
Secco, MAC
机构：
[1] UFMS, CCBS, Dept Clin Surg, BR-79070900 Campo Grande, MS, Brazil
[2] Univ Fed Santa Catarina, Dept Chem, BR-88040900 Florianopolis, SC, Brazil
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 2006年 / 95卷 / 01期
关键词：
Viagra; sildenafil; bioinorganic chemistry;
D O I：
10.1002/jps.20506
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The interaction of Ca2+-ions with sildenafil citrate (Viagra) leads to the precipitation of a new polymorph variety of sildenafil base. Under the same conditions, Mg2+, Zn2+, and Cd2+ ions form structurally related crystalline complexes of the composition Me2+C28H34N6O11S. Lattice parameters have been determined showing that magnesium compound belongs to an orthorhombic system, while the zinc and cadmium compounds are its monoclinic distortions. All three compounds are thermally stable, undergoing decomposition above 175 degrees C with the consequent formation of carbonates Me2+CO3 and oxides. (c) 2005 Wiley-Liss, Inc.
引用
收藏
页码：225 / 227
页数：3
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