Palladium (0)-catalyzed alkynyl and allenyl iminium ion cyclizations leading to 1,4-disubstituted 1,2,3,6-tetrahydropyridines

被引：34
|
作者：
Tsukamoto, Hirokazu [1 ]
Kondo, Yoshinori [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 26期
关键词：
heterocycles; iminium ions; multicomponent reactions; organoboron reagents; palladium;
D O I：
10.1002/anie.200800823
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) The biologically important title heterocyclic compounds can be synthesized by two methods based on the cyclization of alkynyl and allenyl iminium ions generated in situ in the presence of organometallic reagents (see scheme). Symmetrical and unsymmetrical tetrahydropyridines with diverse substituents R4 were prepared in a single step under mild conditions. R1 = n-, sec-, tert-alkyl; R4 = aryl, 1-alkenyl, alkyl, 1-alkynyl, B(pinacolato). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4851 / 4854
页数：4
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