Stereoselectivity in the double reductive alkylation of pyrroles:: synthesis of cis-3,4-disubstituted pyrrolidines

被引：10
|
作者：
Donohoe, TJ
Harji, RR
Cousins, RPC
机构：
[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
来源：
CHEMICAL COMMUNICATIONS | 1999年 / 02期
关键词：
D O I：
10.1039/a809193e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The preparation and Birch reduction of a 1,3,4-tri-substituted pyrrole is described: the heterocycle is loaded with electron-withdrawing groups and undergoes a double reductive alkylation reaction to yield cis-3,4-disubstituted pyrrolidines.
引用
收藏
页码：141 / 142
页数：2
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