Osteonecrosis of the Jaw in a Patient Presenting With Post-Transplantation Lymphoproliferative Disorder Treated With Rituximab: A Case Report

被引：14
|
作者：
Keribin, Pierre [1 ]
Guerrot, Dominique [2 ,3 ]
Jardin, Fabrice [4 ,5 ]
Moizan, Herve [1 ]
机构：
[1] Rouen Univ Hosp, Dept Oral Surg & Odontol, Rouen, France
[2] Normandie Univ, INSERM, U1096, UNIROUEN, Rouen, France
[3] Univ Rouen, Dept Nephrol, Rouen, France
[4] Normandie Univ, INSERM, U918, UNIROUEN, Rouen, France
[5] Henri Becquerel Canc Ctr, Dept Clin Hematol, Rouen, France
来源：
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2017年 / 75卷 / 12期
关键词：
MONOCLONAL-ANTIBODY; ASSOCIATION; BISPHOSPHONATE; LEUKEMIA;
D O I：
10.1016/j.joms.2017.05.016
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Osteonecrosis of the jaw (ONJ) is a rare but potentially severe condition that can be induced by specific treatments. We report the case of a 69-year-old male kidney transplant recipient who presented with ONJ 5 years after transplantation. The patient presented with ulcerations of the oral mucosa related to post-transplantation lymphoproliferative disorder, which was treated with rituximab. Subsequently, ONJ developed. Although rituximab treatment cannot be firmly established as the cause of this condition, similar cases of ONJ have been reported after treatment with this monoclonal antibody. This case raises a potential link between rituximab treatment and ONJ and prompts further studies to investigate the potential impact of rituximab on bone angiogenesis. (C) 2017 American Association of Oral and Maxillofacial Surgeons
引用
收藏
页码：2599 / 2605
页数：7
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