Methicillin-resistant Staphylococcus aureus nasal colonization in people living with HIV and healthy people in Kathmandu, Nepal

Aim: This study aimed to compare methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization in people living with HIV (PLHIV) and healthy people from Kathmandu. Methods: MRSA isolated from 400 nasal swabs was screened using a cefoxitin disc and confirmed by the presence of the mecA gene. Results: MRSA nasal carriers among the PLHIV and control cohorts were 3.5% (7 out of 200) and 5.0% (10 out of 200), respectively. All the MRSA from PLHIV and most of MRSA from healthy controls were PVL positive. Longer duration of antiretroviral therapy significantly reduces the risk of MRSA nasal colonization in PLHIV. Conclusion: There is no significant difference in MRSA nasal colonization in PLHIV and healthy controls in this study region. Lay Abstract: People living with HIV (PLHIV) are more prone to the colonization of Staphylococcus aureus (S. aureus) and therefore to methicillin resistance S. aureus (MRSA). In this study, we compared the MRSA colonization in PLHIV with that in healthy people in the Kathmandu Valley and found no significant variation in the prevalence of MRSA in the two study groups. We found that longer antiretroviral therapy reduces the risk of MRSA colonization in PLHIV. Recent history of hospitalization increases the chances of MRSA colonization among PLHIV as well as healthy people.