The Roles of lncRNA in Myocardial Infarction: Molecular Mechanisms, Diagnosis Biomarkers, and Therapeutic Perspectives

被引：40

作者：

Xie, Luhan ^{[1
]}

Zhang, Qingqing ^{[1
]}

Mao, Jun ^{[1
]}

Zhang, Jun ^{[2
]}

Li, Lianhong ^{[1
]}

机构：

[1] Dalian Med Univ, Coll Basic Med Sci, Dept Pathol & Forens Med, Dalian, Peoples R China

[2] Dalian Med Univ, Dept Teaching Affairs, Dalian, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

关键词：

myocardial infarction; long non-coding RNAs; ceRNA; exosome; biomarker; LONG NONCODING RNAS; INFLAMMATORY RESPONSE; HEART-FAILURE; PROGNOSTIC BIOMARKERS; PROGRAMMED NECROSIS; CARDIAC DEVELOPMENT; REPERFUSION INJURY; GENOME REGULATION; REVEALS; DIFFERENTIATION;

D O I：

10.3389/fcell.2021.680713

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In recent years, long non-coding RNAs (lncRNAs) have been demonstrated to be associated with many physiological and pathological processes in cardiac. Recent studies have shown that lncRNAs are expressed dynamically in cardiovascular diseases and participate in regulation through a variety of molecular mechanisms, which have become a critical part of the epigenetic and transcriptional regulatory pathways in heart development, as well as the initiation and progress of myocardial infarction. In this review, we summarized some current research about the roles of lncRNAs in heart development and myocardial infarction, with the emphasis on molecular mechanisms of pathological responses, and highlighted their functions in the secondary changes of myocardial infarction. We also discussed the possibility of lncRNAs as novel diagnostic biomarkers and potential therapeutic targets for myocardial infarction.

引用

页数：14

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