Palladium-Catalyzed Carbonylative Heck-Type Reactions of Alkyl Iodides

被引：94
|
作者：
Bloome, Kayla S. [1 ]
Alexanian, Erik J. [1 ]
机构：
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 37期
关键词：
OXIDATIVE-ADDITION; COUPLING REACTIONS; BOND FORMATION; HALIDES; COMPLEXES; DERIVATIVES; CYCLIZATION; BROMIDES;
D O I：
10.1021/ja1053913
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium-catalyzed carbonylative Heck-type cyclization of alkyl halides is described. Treatment of a range of primary and secondary alkyl iodides with catalytic palladium(0) under CO pressure forms a variety of synthetically versatile enone products. The reactivity described represents a rare example of a palladium-catalyzed Heck-type cyclization involving unactivated alkyl halides with beta-hydrogens. Alkene substitution is well tolerated, and mono- and bicyclic carbocycles may be easily accessed.
引用
收藏
页码：12823 / 12825
页数：3
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