Al(OTf)3: an efficient recyclable catalyst for direct nucleophilic substitution of the hydroxy group of propargylic alcohols with carbon- and heteroatom-centered nucleophiles to construct C-C, C-O, C-N and C-S bonds

被引：44

作者：

Gohain, Mukut ^{[1
]}

Marais, Charlene ^{[1
]}

Bezuidenhoudt, Barend C. B. ^{[1
]}

机构：

[1] Univ Orange Free State, Dept Chem, ZA-9300 Bloemfontein, South Africa

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 09期

关键词：

Aluminum triflate; Propargylic alcohols; Nucleophiles; Regioselectivity; ONE-POT SYNTHESIS; AROMATIC-COMPOUNDS; ALUMINUM TRIFLATE; SYNTHETIC ROUTE; BENZYL ALCOHOLS; ACETATES; ALKYNYLATION; ACTIVATION; COMPLEXES; OXAZOLES;

D O I：

10.1016/j.tetlet.2011.12.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and highly efficient Al(OTf)(3)-catalyzed methodology has been developed for the direct nucleophilic substitution of the hydroxy group in propargylic alcohols with a variety of carbon- and heteroatom-centered nucleophiles such as alcohols, aromatic compounds, amides, and thiols, leading to the construction of C-C, C-O, C-N and C-S bonds. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1048 / 1050

页数：3

共 18 条

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