A series of enediynes as novel inhibitors of topoisomerase I

被引：23
|
作者：
Lin, CF
Hsieh, PC
Lu, WD
Chiu, HF
Wu, MJ [1 ]
机构：
[1] Kaohsiung Med Univ, Sch Chem, Kaohsiung, Taiwan
[2] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 07期
关键词：
D O I：
10.1016/S0968-0896(01)00081-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of acyclic enediynes, 2-((6-substituted)-3-hexen- 1,5-diynyl)benzonitriles (8-11), display potent inhibition against topoisomerase I without the formation of active biradical intermediates and show inhibitory activity against topoisomerase I at 10 muM, which is five times that of camptothecin from the results of agarose gel electrophoresis. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1707 / 1711
页数：5
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