A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

被引：11
|
作者：
Gigante, A. [1 ]
Grad, J. -N. [2 ]
Briels, J. [1 ,3 ,4 ]
Bartel, M. [1 ,3 ,4 ]
Hoffmann, D. [2 ]
Ottmann, C. [1 ,3 ,4 ]
Schmuck, C. [1 ]
机构：
[1] Univ Duisburg Essen, Inst Organ Chem, Univ Str 7, D-45141 Essen, Germany
[2] Univ Duisburg Essen, Bioinformat & Computat Biophys, D-45141 Essen, Germany
[3] Tech Univ Eindhoven, Inst Complex Mol Syst, POB 513, NL-5600 MB Eindhoven, Netherlands
[4] Tech Univ Eindhoven, Dept Biomed Engn, POB 513, NL-5600 MB Eindhoven, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 01期
关键词：
SMALL-MOLECULE STABILIZATION; HUMAN BETA-TRYPTASE; CHANNELS; BINDING; INHIBITORS;
D O I：
10.1039/c8cc07946c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the first supramolecular stabilizers of the interaction between 14-3-3 and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.
引用
收藏
页码：111 / 114
页数：4
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